Some species of Geckos of specialised toe pads that enable them to climb vertical surfaces while Lizards aren't known to have them.While some species of Geckos may expel a foul spelling material and feces on to their aggressors in defense, lizards aren't known to do that.
Lizards possess external ears and movable eyelids while Geckos have no eyelids but have a transparent membrane which they lick to clean. #Wizards lizard wiki skin
While most lizards have dry and scaly skin, the Gecko's skin is thin with small bumps on it. Both have certain species that can change colors to camouflage. Both the animals are four legged and cold blooded. Only two varities of lizards are known to be venomous. Not venomous though of late some venomous varities have been discovered. Lizards feed on a wide variety of foods including fruits and vegetation, insects, small tetrapods, carrion Many larger species, such as the Caledonian gecko, pursue young lizards, mice, and small birds The common gecko eats beetles, butterflies, millipedes, crickets, and cockroaches. The female lizards do not care for their babies. Still other lizard species may give birth to live young. Others may give birth after hatching their eggs inside the body. The female house gecko lays four or five pairs of eggs between May and August, with two to four weeks between layings. Like most reptiles, the majority of geckos lay eggs. Have four legs, movable eyelids, scaly skin and are cold blooded. Have broad toes and big eye pupils and scaly skin. 
Lizards are reptiles of the order Squamata, normally possessing four legs, external ear openings and movable eyelids
Geckos are small to average sized lizards which are found in warm climates throughout the world Differences - Similarities - Gecko versus Lizard comparison chart
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